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The game begins with Reed, Sue, and Johnny on a roof lying helpless after being knocked unconscious by a blast from Doctor Doom. Sue is the first to recover, so when she sits up and turns around, Dr. Doom is preparing to fire an electric blast at them. Sue holds it off with her force field and calls Ben Grimm for help. Then it cuts away to Ben, who is recovering in the transformation chamber after having his rocklike exterior genetically removed from him. As he contemplates why the circumstances have led to this, he remembers the period when all of this happens.
This is when it reverts to the beginning of the movie: Reed signs the pact, they go into space, and Ben gets the samples ready. In space, they are hit by a cosmic storm which alters their DNA and gives them superpowers. If it hadn’t been for Victor, they might never have arrived back on Earth and into his medical compound, where they recovered. When Ben discovers that he has become a monster-like figure, he deserts the other three and heads home.